Application of 3972-64-3, A common heterocyclic compound, 3972-64-3, name is 1-Bromo-3-(tert-butyl)benzene, molecular formula is C10H13Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(9-1) Synthesis of (9-1)1-(t-butyl)-3-methylbenzene 1-Bromo-3-(t-butyl)benzene(20.26 g, 95.1 mmol) was dissolved in diethyl ether(200 mL), {1,1′-bis(diphenylphosphino)ferrocenyl}nickel dichloride(1.00 g, 1.46 mmol) was added. Solution of methylmagnesium bromide in diethyl ether(3.00 M, 35.00 mL) was dropped at -85¡ãC, and after elevating temperature naturally, reaction solution was stirred for 1 hour at -5¡ãC, and water(30 mL) was added. Solution was washed with hydrochloric acid and water, and organic layer was extracted with diethyl ether. Organic layer was dried over magnesium sulfate, then, solvent was distilled off to obtain the crude product. This was purified by silica-gel column chromatography to obtain the desired 1-(t-butyl)-3-methylbenzene(13.58 g, 91.6 mmol).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Japan Polypropylene Corporation; NAKANO, Masato; UCHINO, Hideshi; IWAMA, Naoshi; KASHIMOTO, Masami; KATO, Tomohiro; EP2360163; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary