Application of 138526-69-9, A common heterocyclic compound, 138526-69-9, name is 1-Bromo-3,4,5-trifluorobenzene, molecular formula is C6H2BrF3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a 500 ml three-neck bottle by adding 31.2g (0.1mol) I-18-b, 23.2g (0.11mol) 3,4,5-trifluorobromobenzene (reactant), 31.8g (0.3mol) sodium carbonate (reactant), 1g tetrakis(triphenylphosphine)palladium (catalyst), 80 ml toluene (solvent), 60 ml ethanol (solvent), 60 ml of deionized water (solvent), under the protection of nitrogen is heated to reflux, reflux the reaction for 6 hours, then cooled to room temperature, liquid, with 50 ml * 2 toluene extraction aqueous phase two, combined with the phase, and then using 100 ml * 2 saturated sodium chloride solution to wash the organic phase, dried with anhydrous sodium sulfate the organic phase, then filtering the desiccant, the concentrated to remove the solvent, after column chromatography using normal hexane-hexane recrystallization for 2 times, get 27.8g (0.07mol) I-14 of target product, yield: 70%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shijiazhuang Chengzhi Yonghua Display Materials Co., Ltd.,; HAN, YAOHUA; TIAN, QIUFENG; LIU, RENJIE; ZHANG, FANGMIAO; LI, HONGFENG; SHI, ZHENG; HUA, RUIMAO; (30 pag.)CN103787826; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary