6274-57-3, name is 1-(4-Bromophenyl)-N,N-dimethylmethanamine, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 6274-57-3
2-Methoxy-3-amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (200 mg, 0.80 mmol, 1 equivalent) was dissolved in toluene (8 mL) and ethanol (2 mL) and then 1-(4-bromophenyl)-N,N-dimethylmethylamine (205 mg, 0.96 mmol, 1.2 equiv-alents) was added followed by tetrakis(triphenylphosphine)palladium(0) (46.2 mg, 0.04 mmol, 0.05 equivalents). Sodium carbonate (585 mg, 5.52 mmol, 6.9 equivalents) and water (3.5 mL) were then added and the reaction mixture heated to reflux for 2 hours under argon. After cooling the solution was diluted with water (15 mL) and extracted with EtOAc (3×50 mL) and the organic layers collected and washed with brine. The organic layers were then dried over magnesium sulfate and concentrated. The residue was purified using an SCX column (eluted with 2 M ammonia in methanol) to give a grey solid (147 mg, 71.4%).
The synthetic route of 6274-57-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Fearon, Daren; Westwood, Isaac M.; van Montfort, Rob L.M.; Bayliss, Richard; Jones, Keith; Bavetsias, Vassilios; Bioorganic and Medicinal Chemistry; vol. 26; 11; (2018); p. 3021 – 3029;,
Bromide – Wikipedia,
bromide – Wiktionary