Reference of 626-40-4,Some common heterocyclic compound, 626-40-4, name is 3,5-Dibromoaniline, molecular formula is C6H5Br2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under N2, 3,5-dibromoaniline (502 mg, 2.0 mmol), Pd (PPh3) 2Cl2 (84.0 mg, 0.12 mmol) and LiCl (672 mg, 16.0 mmol) were added to the dried pressure tube in this order, N2 sealed after pumping three times,20 mL of re-distilled toluene and 2-fluoro-6- (tributylstannyl) pyridine (1.62 g, 4.2 mmol) were injected using a syringe. After 15 minutes, N2 was bubbled and the tube was heated to 120 C for 48 hours. After the reaction is completed, the reaction The solution was cooled to room temperature and suction filtered. The residue was washed with dichloromethane (5 mL ¡Á 2). The combined organic layers were dried over MgSO 4, filtered and concentrated Purification by column chromatography (eluent: methylene chloride / ethyl acetate 1/1, v / v) afforded 340 mg of a yellow solid in a yield of 60%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dibromoaniline, its application will become more common.
Reference:
Patent; Chinese Academy Of Sciences Chemical Institute; Zhong Yuwu; Gong Zhongliang; (24 pag.)CN106831882; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary