460-00-4, name is 1-Bromo-4-fluorobenzene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C6H4BrF
General procedure: This compound was synthesized by the same method as that reported in our previous works.[8], 8(a), 8(b), [9] and 9(a) Compound 7a was prepared by reacting compound 6 (4.0 g, 18.1 mmol) with 4-bromoanisole (3.4 g, 18.1 mmol) in the presence of Pd(PPh3)4 and Na2CO3 (6.40 g, 60 mmol) in tetrahydrofuran (80 mL containing 10% water) for 15 h at 70 C. The product 7a was purified by column chromatography on SiO2 using hexane as an eluent and 3.8 g obtained as a pale yellow solid in 78% yield.
The synthetic route of 460-00-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Pu, Shouzhi; Li, Hui; Liu, Gang; Liu, Weijun; Cui, Shiqiang; Fan, Congbin; Tetrahedron; vol. 67; 7; (2011); p. 1438 – 1447;,
Bromide – Wikipedia,
bromide – Wiktionary