Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 586-61-8, name is 1-Bromo-4-isopropylbenzene, A new synthetic method of this compound is introduced below., Safety of 1-Bromo-4-isopropylbenzene
Under a stream of nitrogen, 2.55 g (105 mmol) of magnesium and 50 ml of anhydrous THF were put into a nitrogen-replaced 300 ml capacity reaction flask, followed by stirring. At room temperature, a 30 ml THF solution of 19.91 g (100 mmol) of 4-t-propylphenylbromobenzene was added dropwise thereto, followed by stirring at room temperature for 1 hour (synthesis of a Grignard compound).Next, the above-mentioned solution was cooled to 5 C. or less, and 10.05 g (50 mmol) of the (S)-proline-N-ethyl carbamate methyl ester obtained in Synthesis Example 2 was added dropwise thereto at 10 C. or less and allowed to undergo the reaction. Thereafter, this was heated under reflux for 3 hours and then cooled, and the reaction solution was added to 100 ml of saturated ammonium chloride aqueous solution, mixed with 100 ml of toluene for extraction, followed by stirring for 1 hour. This was transferred to a separating funnel, and the organic layer was separated and washed twice with saturated brine. After drying the organic layer with anhydrous sodium sulfate, the solvent was evaporated to obtain 16.22 g of (5S)-[3,3,0]-1-aza-2-oxo-3-oxa-4,4-bis-(4′-i-propylphenyl)-bicyclooctane.
The synthetic route of 586-61-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TAKASAGO INTERNATIONAL CORPORATION; US2010/324338; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary