Adding a certain compound to certain chemical reactions, such as: 6911-87-1, name is 4-Bromo-N-methylaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6911-87-1, Recommanded Product: 6911-87-1
2 mmol of trifluoroethylamine hydrochloride, 1 mL of water, 34 uL of acetic acid, and 1 mL of dichloroethane were placed in a reaction tube, and a rubber stopper was placed and fixed on a stirrer. Take 42 mg of sodium nitrite in a 1.5 mL sample tube, add 1 mL of water to the sample tube, and shake the sample.The tube is dissolved in sodium nitrite. dissolving the dissolved sodium nitrite solution into the reaction tube with a syringe, Stir for half an hour at room temperature.Dissolve the iron porphyrin of formula 3 with 1 mL of dichloromethane (R1 = calixarene, R2 = R3 = CN, L = OAc)(catalytic amount, 9/1000 of the molar amount of secondary amine), 0.24 mmol of 4-bromo-N-methylaniline was taken in the sample tube. After half an hour, put the sample tube the internal mixed solution is added dropwise to the reaction tube, and stirred while being added.The temperature was raised to 80 C for 12 hours. The reaction solution is cooled to room temperature and passedPart of the impurities are removed by filtration, concentrated and purified by column chromatography to obtain the desired product. The column chromatography eluent is petroleum ether andA mixed solvent of acetone. The structure of 4-bromo-N-methyl-N-(2,2,2-trifluoroethyl)aniline is as follows:The compound was a pale yellow liquid with a yield of 73% and its nuclear magnetic data was as follows:
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-N-methylaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Yuanjiang Hualong Catalysis Technology Co., Ltd.; Liu Qiang; Xu Guiming; Guo Cancheng; (16 pag.)CN108997145; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary