Synthetic Route of 59907-13-0, These common heterocyclic compound, 59907-13-0, name is 2-Bromo-1-fluoro-3-methylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-bromo-3-fluorotoluene (1.89 g, 10 mmol),Carbazole (1.67 g, 10 mmol) and cesium carbonate (6.52 g, 20 mmol)Add 15mL dimethylformamide (DMF),The mixture was stirred at 150C for 12 hours, poured into 200 ml of water, and the precipitate was collected by filtration.After column purification, white solid 9-(2-bromo-3-methylphenyl)carbazole (3.1 g) was obtained with a yield of 92%.
The synthetic route of 59907-13-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chinese Academy Of Sciences Fujian Structure Of Matter Institute; Lu Canzhong; Chen Xulin; Jia Jihui; (22 pag.)CN107698613; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary