Application of 67567-26-4, These common heterocyclic compound, 67567-26-4, name is 4-Bromo-2,6-difluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 4-bromo-2,6-difluoroaniline (2.62 g, 12.6 mmol), methanesulfonyl chloride (1.73 g, 15.1 mmol) and 4-(dimethylamino)pyridine (461 mg, 3.78 mmol) in anhydrous pyridine (35 ml) was stirred for 15 hours at ambient temperature. The mixture was diluted with ethyl acetate (15 ml) and washed with 2M hydochloride aqueous solution until the aqueous pH 2, brine, dried over sodium sulfate. After filtration to separate solvent and sodium sulfate, the solvent was removed under reduced pressure to give a residue, which was applied to a silica gel chromatography column and eluted with hexane/ethyl acetate =5/1 to furnish 2.20 g (48 % yield) of the title compound as a white solid. 1H NMR (DMSO-d6, 270 MHz) delta ppm 3.55 (6H, s), 7.78-7.85 (2H, m)
The synthetic route of 67567-26-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Pfizer, Inc.; US2006/100460; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary