Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 72678-19-4, name is 2,6-Dibromo-4-(trifluoromethyl)aniline, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H4Br2F3N
A mixture of 2,6-dibromo-4-trifluoromethylaniline (manufactured by Wako Pure Chemicals, 0.78 g, 2.45 mmol) and 95% sulfuric acid (1.5 mL) was cooled to an internal temperature of 0 C., and 40% nitrosylsulfuric acid (0.85 g, 2.67 mmol) was dropwise added thereto at the internal temperature kept at 0 C. This was stirred for 1 hour at an internal temperature of from -2 C. to 0 C., and with cooling with ice, this was poured into 5 mL of ice in water to give a diazo liquid. In a separate vessel, the intermediate A-1 (1.00 g, 2.67 mmol) was dissolved in acetic acid (2 mL), and dropwise added to the resultant diazo liquid at an internal temperature of 0 C. or lower. After the addition, this was left at 0 C. for 1 hour, then extracted with toluene, and the toluene layer was washed with water and saturated saline water, and dried with anhydrous sodium sulfate. This was concentrated under reduced pressure, and purified through silica gel column chromatography to give an intermediate C-1 (0.33 g, yield 19%) as a reddish tar-like substance.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MITSUBISHI CHEMICAL CORPORATION; SHIGA, Yasushi; AOBA, Mitsuya; TANAKA, Yuki; ISHIDA, Mio; US2015/191601; (2015); A1;,
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bromide – Wiktionary