Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1003-99-2, name is 2-Bromo-5-fluoroaniline, A new synthetic method of this compound is introduced below., COA of Formula: C6H5BrFN
3-methyl-4-nitrobenzoyl chloride (5.496g, 27.62 mmol) dissolved in 2 mL of dry pyridine was added to a stirringsolution of 2-bromo-5-fluoroaniline (5.248 g, 27.62 mmol) in dry pyridine (10mL). The dark brown solution was heated under reflux for 2 hours, then pouredinto water (30 mL), forming a precipitate that was collected and washed withwater and methanol, to afford a white solid (8.128 g, 84percent yield). 1HNMR (400 MHz, DMSO-d6): 10.38 (bs, 1H, NH-CO)delta, 8.13 (d, J=8.6 Hz, 1H, H-5?), 8.07 (bs, 1H, H-2?), 8.00 (dd, J=2.3, 8.7 Hz, 1H, H-6?), 7.78 (dd, J=5.8, 9.0 Hz, 1H, H-3), 7.53 (dd, J= 3.2, 9.9 Hz, 1H, H-6), 7.18 (td, J=8.7 Hz, 3.32, 1H, H-4), 2.59 (s, 3H,CH3); 13C NMR (100 MHz, DMSO-d6): delta 164.43,162.78, 160.35, 151.29, 138.04, 134.35, 133.36, 132.57, 127.07, 125.10, 116.32,116.08, 115.70, 19.80. MS: m/z (HRMS)calcd. for C14H11BrFN2O3+352.9932, 354.9912 [M+H], MS found: 354.9938 [M+H].
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Stone, Erica L.; Citossi, Francesca; Singh, Rajinder; Kaur, Balvinder; Gaskell, Margaret; Farmer, Peter B.; Monks, Anne; Hose, Curtis; Stevens, Malcolm F.G.; Leong, Chee-Onn; Stocks, Michael; Kellam, Barrie; Marlow, Maria; Bradshaw, Tracey D.; Bioorganic and Medicinal Chemistry; vol. 23; 21; (2015); p. 6891 – 6899;,
Bromide – Wikipedia,
bromide – Wiktionary