Application of 630-17-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 630-17-1 as follows.
To a solution of trans-N-(4-furo [3 ,2-b]pyridin-3 -ylcyclohexyl)- 1H-pyrazole-4-sulfonamide (20 mg, 1 equiv.) in DMF (1 mL), K2C03 (23.6 mg, 3 equiv.) was added, followed by 1- bromo-2,2-dimethyl-propane (10.8 tL, 1.5 equiv.). The reaction mixture was stirred for 30 mm at 150 C by using microwave irradiation, and was then purified by preparative HPLCMS to afford the expected product (8 mg). LCMS: MW (calc?d): 416.5; MS (ES, m/z):417.7 [M+H].
According to the analysis of related databases, 630-17-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; E-THERAPEUTICS PLC; KOLUND?IC, Filip; MILEK, Mateja; POLJAK, Tanja; RO?CIC, Maja; STUBBERFIELD, Colin; VADLAMUDI, Srinivasamurthy; (139 pag.)WO2019/43373; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary