Synthetic Route of 18392-81-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18392-81-9, name is 5,6-Dibromobenzo[c][1,2,5]thiadiazole belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Take 100mL reaction tube,5,6-dibromobenzothiadiazole (2.94 g, 10 mmol) was added,2-dodecylthiophene (2.77 g, 11 mmol),Potassium carbonate (1.66 g, 12 mmol),Trimethylacetic acid (306 mg, 3 mmol),5% of the catalyst palladium acetate,Nitrogen vacuum drum,30 mL of anhydrous N, N-dimethylacetamide was injected with a syringe,Stir at room temperature for 1 minute to make it fully dissolved,110 C for 4 hours.After completion of the reaction, the mixture was extracted with ethyl acetate,Add more saturated salt water layer is more obvious.Dried over anhydrous sodium sulfate,The solvent was removed under reduced pressure to give the crude product,Column chromatography,Petroleum ether / dichloromethane (8: 1).To give the product 1a (2.79 g, 60%),Light yellow oily liquid.
The synthetic route of 5,6-Dibromobenzo[c][1,2,5]thiadiazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing University of Posts and Telecommunications; Fu, Nina; Huang, Wei; Shi, Xin; Zhao, Baomin; Liu, Shuli; Wang, Lianhui; (15 pag.)CN106008558; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary