The synthetic route of 54962-75-3 has been constantly updated, and we look forward to future research findings.
Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 54962-75-3, name is 3-Bromo-5-(trifluoromethyl)aniline, A new synthetic method of this compound is introduced below., Product Details of 54962-75-3
A solution of l-allyl-4-methylpiperazine (2.12 g, 14.0 mmol) and 9-BBN (0.5 M in THF, 1.7 g, 28 mL, 14.0 mmol) was EPO heated at reflux for 3 h and then cooled to RT. The solution was added to a mixture of 3-bromo-5- (trifluoromethyl)aniline (3.Oo g, 12.5 ittmol) , potassium carbonate (8.64 g, 62.5 mmol) , PdCl2(PPh3J2-CH2Cl2 adduct (0.457 g, 0.6 mmol) , DMF (30 mL) and water(2 mL) . The mixtre was heated to 75C for 24. The mixture was concentrated, triturated with dichloromethane, and filtered. The filtrate was concentrated and the residue was purified via column chromatography on silica gel (gradient elution with 0-20% methanol-dichloromethane) to afford 3- (3- (4-methylpiperazin- 1-yl)propyl) -5- (trifluoromethyl)benzenamine as a brown oil. MS m/z = 302 [M+H]+. CaIc’d for C15H22F3N3: 301.
The synthetic route of 54962-75-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; WO2006/44823; (2006); A2;,
Bromide – Wikipedia,
bromide – Wiktionary