Electric Literature of 167355-41-1, The chemical industry reduces the impact on the environment during synthesis 167355-41-1, name is 6-Bromo-1,2,3,4-tetrahydronaphthalen-2-amine, I believe this compound will play a more active role in future production and life.
Di-tert-butyldicarbonate (575.7 mg, 2.64 mmol) in methylene chloride (5.0 mL) is added in one portion to a solution of methylene chloride (7.0 mL) at room temperature that contains (rac)- 6-Bromo-l,2,3,4-tetrahydronaphthalen-2-ylamine (591.6 mg, 2.62 mmol) and triethylamine (1.1 mL, 7.89 mmol). After stirring at room temperature for 19 h in air, the resulting amber solution is diluted with methylene chloride (25 mL), washed with a saturated aqueous solution of sodium chloride (2 x 50 mL), dried over magnesium sulfate, and evaporated to dryness under reduced pressure to give the title compound as a pale yellow solid. The purity of isolated 29 was >95%, as determined by 1H NMR spectroscopy, and was used without further purification, mp 107-108 EPO
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Bromo-1,2,3,4-tetrahydronaphthalen-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WO2006/89054; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary