Adding a certain compound to certain chemical reactions, such as: 7073-94-1, name is 1-Bromo-2-isopropylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7073-94-1, name: 1-Bromo-2-isopropylbenzene
1-Bromo-2-isopropylbenzene (15.0 g, 75.3 mmol),4-chlorophenylboronic acid (14.1 g, 90.4 mmol),Tetrakistriphenylphosphine palladium (1.74 g, 1.51 mmol),Potassium carbonate (20.8 g, 151 mmol),Tetrabutylammonium bromide 4.86 g, 15.1 mmol),Toluene (80mL),Ethanol (80 mL) and deionized water (80 mL) were added to a round bottom flask.Raise to 75-80 C under nitrogen atmosphere and stir for 16 hours;The reaction solution was cooled to room temperature, and toluene (150 mL) was added for extraction.The organic phases were combined, dried over anhydrous magnesium sulfate and filtered.The solvent is removed under reduced pressure;The obtained crude product was recrystallized and purified using a dichloromethane/n-heptane system.Intermediate I-B-1 (7.89 g, 45%) was obtained as a yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-isopropylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shanxi Laite Optoelectric Materials Co., Ltd.; Ma Tiantian; Feng Zhen; Li Hongyan; Li Jian; Sha Xunshan; (37 pag.)CN110105225; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary