Electric Literature of 1435-52-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1435-52-5, name is 1,4-Dibromo-2-fluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 1,4-dibromo-2-fluorobenzene (6.86 g, 27 mmol), ethanediol (35 mL), N-methylpyrrolidone (35 mL) and potassium tert-butoxide (11.2 g, 95 mmol) was stirred at 100 C overnight under N2. After the mixture was cooled to room temperature, water (15 mL) was added slowly within 30 min. Then the mixture was filtered, and the filter cake was washed by ethanediol. To the filtrate was added water and the mixture was stirred for 30 min. The resulting solution was then cooled to 15 C, and let stay for 1 h. The precipitate was filtered, washed by water, and dried to give the title compound (4.70 g, 59 %). 1H NMR (CDCl3): delta 7.40 (1H, d, J = 8.4 Hz), 7.05 (1H, d, J = 2.4 Hz), 7.02-6.70 (1H, m), 4.14 (2H, t, J = 4.4 Hz), 4.02-3.98 (2H, m), 2.13 (1H, t, J = 6.4 Hz)
The synthetic route of 1,4-Dibromo-2-fluorobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Li, Yuliang; WANG, Huting; ZHU, Yan; WANG, Zhe; ZHANG, Hui; ZHAO, Ruiyu; HUANG, Yuanyuan; WANG, He; PENG, Yong; LUO, Hong; XIAO, Dengming; CAO, Shousong; HAN, Yongxin; EP2862571; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary