Adding a certain compound to certain chemical reactions, such as: 67344-77-8, name is 1-(3-Bromophenyl)-N-methylmethanamine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 67344-77-8, name: 1-(3-Bromophenyl)-N-methylmethanamine
Step 1: tert-Butyl 3-bromobenzyl(methyl)carbamate[00171] BOC20 (1.309 g, 1.378 mL, 5.998 mmol) was added to a stirred solution of l-(3- bromophenyl)-N-methyl-methanamine (1 g, 4.998 mmol) and Ets (606.9 mg, 836.0 mu^, 5.998 mmol) in DCM (20 mL) at ambient temperature and the reaction stirred for 16 hours. The reaction mixture was washed with 0.5M HC1 (x 1), water (x 2) and brine (x 1). The combined organic extractcs were dried (MgS04), filtered and concentrated in vacuo. The residue was purified by column chromatography (ISCO Companion.(TM)., 40 g column, eluting with 0 to 50percent EtO Ac/Petroleum Ether) to give the sub-title product as a colourless oil (1.44 g, 96percent Yield). XH NMR (400.0 MHz, DMSO) d 1.38 – 1.43 (2 x br s, 9H), 2.77 (s, 3H), 4.37 (s, 2H), 7.23 (d, 1H), 7.33 (t, 1H), 7.41 (s, 1H) and 7.48 (d, 1H) ppm; MS (ES+) 302.1.
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Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; CHARRIER, Jean-Damien; DURRANT, Steven, John; KNEGTEL, Ronald, Marcellus Alphonsus; PINDER, Joanne; YOUNG, Stephen, Clinton; REAPER, Philip, Michael; WO2011/143399; (2011); A1;,
Bromide – Wikipedia,
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