Adding a certain compound to certain chemical reactions, such as: 626-40-4, name is 3,5-Dibromoaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 626-40-4, category: bromides-buliding-blocks
3,5-Dichlorobenzoyl chloride (90.3 mg, 0.431 mmol) and 3,5-dibromoaniline (91.2 mg, 0.363 mmol) were stirred in THF (2.0 mL) for 1 h.The reaction was then diluted with H2O (~20 mL) and sonicated, and the resulting precipitate was filtered, rinsed with H2O, collected, sonicated with sat. NaHCO3(~10 mL), filtered, rinsed with H2O, and collected.Flash chromatographic purification over silica (4:1 hexanes:EtOAc) afforded 3,5-dichloro-N-(3,5-dibromophenyl)benzamide (217) as an off-white solid (125 mg, 81%).1H-NMR (500 MHz,d6-DMSO)d10.60 (s, 1H), 8.02 (d,J=1.7 Hz, 2H), 7.96 (d,J=1.9 Hz, 2H), 7.90 (t,J=1.9 Hz, 1H), 7.58 (t,J=1.7 Hz, 1H);13C-NMR (125 MHz, CDCl3)d163.02, 139.32, 136.93, 135.94, 132.22, 130.60, 125.69, 123.21, 121.82; ESI-TOF 421.8341m/z[MH]+, C13H8Br2Cl2NO requires 421.8344; RP-HPLC: 97% pure.
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Reference:
Article; Connelly, Stephen; Mortenson, David E.; Choi, Sungwook; Wilson, Ian A.; Powers, Evan T.; Kelly, Jeffery W.; Johnson, Steven M.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 15; (2017); p. 3441 – 3449;,
Bromide – Wikipedia,
bromide – Wiktionary