Related Products of 858121-94-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 858121-94-5, name is 4-(Bromomethyl)-1,1-difluorocyclohexane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 4-(bromomethyl)-1 ,1-difluorocyclohexane (600 mg, 0.0028 mol, Intermediate 3) in Lambda/,/V-dimethylformamide (6 mL), sodium azide (549 mg, 0.0084 mol) was added at 26 C. The reaction mixture was heated to 100 C and stirred for 16 h at the same temperature. Upon completion, the reaction mixture was used for the next step without any further purification.1H NMR (400 MHz, CDCI3) 53.18 (t, J = 6.6 Hz, 2H), 2.17-1.98 (m, 2H), 1.85-1.57 (m, 5H), 1.37- 1.20 (m, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Bromomethyl)-1,1-difluorocyclohexane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ALEMPARTE-GALLARDO, Carlos; ENCINAS, Lourdes; ESQUIVIAS PROVENCIO, Jorge; (206 pag.)WO2019/34729; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary