Related Products of 615-59-8,Some common heterocyclic compound, 615-59-8, name is 1,4-Dibromo-2-methylbenzene, molecular formula is C7H6Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under argon atmosphere, 0.65 g (0.80 mmol) of PdCl2(dppf),5.9 g (60.0 mmol) of potassium acetate, and 15.2 g (60.0 mmol)bis(pinacolato)diboron were weighed into a 100 mL two-neck flask. 5.0 g (20.0 mmol) of 1,4-dibromo-2-methylbenzene and 100mL dry1,4-dioxane were added to the solution. After stirring at 100 C for24 h, the solution was stirred further night at room temperature, and the solvent was removed in vacuum. The residue was purified by column chromatography using silica gel (n-hexane/ethyl acetate 50:1). The product was recrystallized with dichloromethane andethanol. The product was a white solid. Yield: 5.1 g (74%). 1H NMR d:7.76 (s, 1H), 7.61 (s, 2H), 2.55 (s, 3H), 1.36 (s, 24H). 13C NMR d:143.83, 135.87, 135.03, 130.84, 83.78, 83.50, 77.46, 77.04, 76.61,24.90, 24.87, 22.03. MS (EI) m/z: 344.3(M).
The synthetic route of 615-59-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Park, Soyun; Tan, Xiaofeng; Jang, Woongsik; Cho, Jae Sang; Kim, Yun-Hi; Kwon, Soon-Ki; Wang, Dong Hwan; Organic electronics; vol. 46; (2017); p. 183 – 191;,
Bromide – Wikipedia,
bromide – Wiktionary