Sources of common compounds: 656-64-4

The synthetic route of 3-Bromo-4-fluoroaniline has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 656-64-4, name is 3-Bromo-4-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 3-Bromo-4-fluoroaniline

General procedure: To a solution of 4-chloro-2-methyl-6-nitroquinoline 12 (2.67g, 12.0mmol) and aniline 13b (1.34g, 14.4mmol) in 30mL of isopropanol (IPA) was added HCl (2 drops) at room temperature. The reaction mixture was then heated at reflux temperature for 3h. Resulting solution was cooled to room temperature. Solid separated was collected by filtration and washed with IPA. The crude product obtained was crystallized from EtOH/CH2C2 to give 14b, 1.91g (57%).

The synthetic route of 3-Bromo-4-fluoroaniline has been constantly updated, and we look forward to future research findings.

Reference:
Article; Marvania, Bhavin; Kakadiya, Rajesh; Christian, Wilson; Chen, Tai-Lin; Wu, Ming-Hsi; Suman, Sharda; Tala, Kiran; Lee, Te-Chang; Shah, Anamik; Su, Tsann-Long; European Journal of Medicinal Chemistry; vol. 83; (2014); p. 695 – 708;,
Bromide – Wikipedia,
bromide – Wiktionary