Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 126930-72-1, name is 1-Bromo-4-dodecylbenzene, This compound has unique chemical properties. The synthetic route is as follows., category: bromides-buliding-blocks
To a suspension of 1 -bromo-4-dodecylbenzene (3.626 g, 1 1 .15 mmol) in anhydrous tetrahydrofuran (48 cm3) at -78 C, ferf-butyllithium (13 cm3, 22 mmol, 1 .7 M in pentane) is added dropwise over 30 minutes. After 40 minutes the reaction is allowed to warm to -30 C before the reaction mixture is then re-cooled to -78 C. Additional 1 -bromo-4-dodecylbenzene (362 mg, 1 .1 1 mmol) is added and after 15 minutes ethyl 2-[5-(3- ethoxycarbonyl-2-thienyl)thieno[3,2-b]thiophen-2-yl]thiophene-3- carboxylate (1 .00 g, 2.23 mmol) is added in one portion to the reaction mixture. This mixture is then allowed to stir at -78 C for 20 minutes before removing allowing the mixture to warm to 23 C. Water (100 cm3) is added and the mixture stirred for 5 minutes. Diethyl ether (50 cm3) is then added and the organic layer extracted. The organic extract is then washed with saturated ammonium chloride solution (100 cm3), water (100 cm3) and brine (100 cm3), dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo. The crude is purified by column chromatography eluting with a graded solvent system (40-60 petrol:dichloromethane; 1 :0 to 3:2) with final purification achieved by trituration with methanol (3 x 10 cm3), washing the filtered solid with 40-60 petrol (2 x 10 cm3), diethyl ether (10 cm3) and acetone (10 cm3) to give intermediate 38 (2.09 g, 70%) as a yellow solid. 1H NMR (400 MHz, CDCIs) 7.12 – 7.17 (10H, m), 7.07 – 7.12 (8H, m), 6.64 (2H, s), 6.45 (2H, d, J 5.2), 3.24 (2H, s), 2.60 (8H, t, J 7.7), 1 .57 – 1 .65 (8H, m), 1 .25 – 1 .35 (72H, m), 0.89 (12H, t, J 6.8).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 126930-72-1.
Reference:
Patent; MERCK PATENT GMBH; MORSE, Graham; NANSON, Lana; MITCHELL, William; KROMPIEC, Michal; D’LAVARI, Mansoor; PRON, Agnieszka; (327 pag.)WO2018/65350; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary