Synthetic Route of 24358-62-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 24358-62-1 as follows.
tert-Butyl 1-(4-bromophenyl)ethylcarbamate 1-(4-Bromophenyl)ethanamine (3.58 ml, 25 mmol) and Et3N (4.39 ml, 31.25 mmol) was dissolved in CH2Cl2 and cooled to 0 C. To this was added (Boc)2O (6.0 g, 27.5 mmol) and the resulting solution was stirred 5 minutes at 0 C. for 5 and then 3 h at room temperature. The reaction was washed with HCl (50 ml, 1M) followed by NaHCO3 (sat) (2*50 ml). The organic phase was dried over MgSO4, filtered and evaporated. The residue was purified by precipitation from MeOH/H2O (10:1) to give 6.35 g (85%) of the title compound as a white powder. 1H NMR (CDCl3) delta 7.45 (d, 2H), 7.18 (d, 2H), 4.83-4.70 (br, 2H), 1.46-1.32 (br, 12H).
According to the analysis of related databases, 24358-62-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; RESPIRATORIUS AB; US2012/40942; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary