Reference of 80058-84-0, A common heterocyclic compound, 80058-84-0, name is 4-Bromo-2,6-diisopropylaniline, molecular formula is C12H18BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
With stirring, 21 g (0.15 mol) of potassium carbonate are initially added to 141 g (1.5 mol) of phenol in 500 g of toluene, followed by the addition of 168 g (1.5 mol) of a 50percent aqueous solution of potassium hydroxide. The entire water of reaction is then separated under reflux, and then ca. 400 g of toluene are removed by distillation. The residue is dissolved in 700 g of dimethyl formamide. After addition of 6 g (0.05 mol) of copper carbonate, solvent is distilled off until the temperature of the reaction mixture is 140¡ã C. Then 256 g (1 mol) of 4-bromo-2,6-diisopropylaniline are added at 140¡ã C. and the mixture is kept for 10 hours at 140¡ã C. The dimethyl formamide is then removed by vacuum distillation, the residue is extracted with water, and the product is taken up in toluene. After stripping off the toluene, the crude product is purified by vacuum distillation, giving 215 g (80percent of theory) of 4-phenoxy-2,6-diisopropylaniline with a boiling point of 142¡ã-145¡ã C./0.04 mbar and a melting point of 69¡ã-71¡ã C., in the form of a bright red product.
The synthetic route of 80058-84-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Ciba-Geigy Corporation; US4997967; (1991); A;,
Bromide – Wikipedia,
bromide – Wiktionary