Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 401-84-3, name is 1,3-Dibromo-5-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., Formula: C7H3Br2F3
With the magnetic force of the rotor to dry the reaction tube by sequentially adding a 9 H – pyrido [2, 3b] indole (5.04 g, 30 . 00 mmol, 1.0 eq), CuI (571.4 mg, 3 . 00 mmol, 0 . 01 eq), L – Proline (690.0 mg, 6 . 00 mmol, 0 . 02 eq) and K2CO3(8.29G,60 . 00mmol,2 . 0 eq). Replacing the nitrogen three times, then adding 1, 3 – dibromo -5 – trifluoromethylbenzene (10.94 g, 36.0 mmol, 1.2 eq) and solvent dimethyl sulfoxide (30 ml). The reaction mixture is 120 C oil bath reaction 1.5 days. Cooling to room temperature, add 100 ml ethyl acetate dilution, diatomaceous earth filter, and ethyl acetate full cleaning, add 50 ml water, liquid, ethyl acetate extraction the aqueous phase three times, the combined organic phase, drying the organic phase with anhydrous sodium sulfate, filtered, reduced pressure distillation to remove the solvent, the obtained crude product by silica gel column chromatography separation and purification, eluent (petroleum ether/dichloromethane=4:1 – 2:1), to obtain white solid 2 – Br – CF35. 15 G, yield 43%. The product can be directly used in the next step of the synthesis.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Zhejiang University of Technology; Ruisheng Optoelectric Science And Technology (Changzhou) Co., Ltd.; Li Guijie; She Yuanbin; Zhao Xiangdong; Chen Shaohai; (38 pag.)CN108948096; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary