Adding a certain compound to certain chemical reactions, such as: 393-36-2, name is 4-Bromo-3-(trifluoromethyl)aniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 393-36-2, Safety of 4-Bromo-3-(trifluoromethyl)aniline
(ii) 4-Cyano-3-(trifluoromethyl)aniline was prepared by the method of L. Friedman and H. Shechter (J. Org. Chem. 26, 2522, 1961)): A mixture of 5-amino-2-bromobenzotrifluoride (12.00 g, 50 mmol), CuCN (5.37 g, 60 mmol), and DMF (7.5 mL) was heated under reflux for 2 h. It was poured into 30% w/v NaCNaq (150 mL) and extracted with ether (75 mL). The ether layer was washed sequentially with 10% NaCNaq (100 mL), H2O (100 mL), and brine (100 mL), dried (Na2SO4) and evaporated to dryness to give the crude product (8.00 g). This was flash chromatographed on silica (700 g) using 20% ether in CH2Cl2 as the eluant to give the pure product as a light tan solid (7.03 g, 76%) suitable for further use. An analytical sample recrystallized from EtOH/H2O as off-white needles, mp 142-143C, NMR satisfactory, Anal. (C8H5F3N2) C,H,N,F.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; AGOURON PHARMACEUTICALS, INC.; EP365763; (1990); A1;,
Bromide – Wikipedia,
bromide – Wiktionary