Related Products of 615-54-3, These common heterocyclic compound, 615-54-3, name is 1,2,4-Tribromobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under an argon stream, 340 mg (1.08 mmol) of 1,2,4-tribromobenzene,100 mg (0.0865 mmol) of tetrakis (triphenylphosphine) palladium,And 4.86 mL (4.86 mmol) of 1 M potassium carbonate aqueous solution were dissolved in 12.5 mL of dioxane,And heated to 100 C.Therein was dissolved in 25 mL of dioxane1- [4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) phenyl] isoquinoline1.25 g (3.78 mmol) was added dropwise over 3 hours,And the mixture was further stirred for 1 hour.After cooling to room temperature, 400 mL of pure water was added and separation and extraction was performed with chloroform. After distilling off the solvent under reduced pressure, the obtained crude product was purified by silica gel column chromatography (developing solvent: chloroform: ethyl acetate = 7: 3)4 ‘- [4- (1-isoquinolyl) phenyl] -1,1’: 2 ‘, 1 “- terphenylOf pale yellow solid (yield 536 mg, yield 72.2%).
Statistics shows that 1,2,4-Tribromobenzene is playing an increasingly important role. we look forward to future research findings about 615-54-3.
Reference:
Patent; TOSOH CORPORATION; FUJITA, KANA; ARAI, NOBUMICHI; NOMURA, KEISUKE; IIDA, TAKASHI; TANAKA, TSUYOSHI; (76 pag.)JP6264877; (2018); B2;,
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