Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 811711-33-8, name is 1,2-Dibromo-3-fluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 811711-33-8
A mixture of 2.5 g (12.23 mmol) of 7,8-difluoro-2-methylquinolin-3-amine and 3.32 g (12.84 mmol) of 1 ,2- dibromo-3-fluorobenzene together with 11.95 mg (36.69 mmol) of cesium carbonate and 708 mg (1.22 mmol) of 9,9-dimethyl-9H-xanthene-4,5-diyl)bis-(diphenylphosphane [Xantphos] in 70 mL of 1 ,4-dioxane was degassed with argon for 30 minutes. 896 mg (0.97 mmol) of tris(dibenzylideneacetone)pailadium(0) was added and the reaction mixture was heated at reflux for 26 hours. The cooled reaction mixture was filtered over a silica gel pad, and the pad washed by ethyl acetate. The organic phase was concentrated under vacuo and purified by column chromatography on silica gel (300 g cartridge – gradient n-heptane/ethyl acetate) to yield 2.31 g (49%) of N-(2-bromo-3-fluorophenyl)-7,8-difluoro-2-methylquinolin-3-amine. LogP = 3.28. Mass (M+H) = 367
According to the analysis of related databases, 811711-33-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BAYER AKTIENGESELLSCHAFT; CRISTAU, Pierre; DESBORDES, Philippe; DUFOUR, Jeremy; GOURGUES, Mathieu; LAMPRECHT, Sybille; LOQUE, Dominique; MEISSNER, Ruth; NAUD, Sebastien; THOMAS, Vincent; (90 pag.)WO2020/79173; (2020); A1;,
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