Reference of 608-30-0,Some common heterocyclic compound, 608-30-0, name is 2,6-Dibromoaniline, molecular formula is C6H5Br2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-chloro-5-methoxyphenylboronic acid (1.25 g, 6.71 mmol), 2,6-dibromoaniline (1.851 g, 7.38 mmol), sodium carbonate (6.71 mL, 13.41 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.465 g, 0.40 mmol) were dissolved in dioxane (10 mL), degassed and sealed into a microwave tube. The reaction was heated to 1500C for 1 hour in the microwave reactor and cooled to room temperature.The reaction mixture was poured into saturated aqueous NH4CI solution (100 mL), extracted with EtOAc (100 mL), and the organic layer was washed with water (50 mL) and saturated brine (50 mL). The organic layer was dried over MgSO4, filtered and evaporated to afford an orange oil. The crude product was purified by flash silica chromatography, elution gradient 0 to 10% EtOAc in isohexane. Pure fractions were evaporated to dryness to afford 3-bromo-2′- chloro-5′-methoxybiphenyl-2-amine (0.993 g, 47 %) as a white solid; 1H NMR (400 MHz, CDCI3) delta 3.73 (3H, s), 3.95 (2H, s), 6.61 (1 H, t), 6.73 – 6.78 (1 H, m), 6.83 (1 H, d), 6.92 – 6.94 (1 H, m), 7.31 – 7.34 (1 H, m), 7.38 – 7.40 (1 H, m)
The synthetic route of 608-30-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KUDOS PHARMACEUTICALS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED; FRIGERIO Mark; HUMMERSONE, Marc, Geoffrey; MENEAR, Keith, Allan; FINLAY, Maurice, Raymond, Verschoyle; GRIFFEN, Edward, Jolyon; RUSTON, Linette, Lys; MORRIS, Jeffrey, James; TING, Attila, Kuan, Tsuei; GOLDING, Bernard, Thomas; GRIFFIN, Roger, John; HARDCASTLE, Ian, Robert; RODRIGUEZ-ARISTEGUI, Sonsoles; WO2010/136778; (2010); A1;,
Bromide – Wikipedia,
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