Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 43204-63-3, name is Bis(2-Bromoethyl)amine hydrobromide, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H10Br3N
Step 4: 4,5-Difluoro-2-(piperazin-1-yl)benzenesulfonamide A mixture of 2-amino-4,5-difluoro-benzenesulfonamide (1.04 g, 5.00 mmol), 2-bromo-N-(2-bromoethyl)ethanamine hydrobromide (15.59 g, 50.00 mmol) and n-butyl alcohol (50.00 mL) was stirred at 120 C. for 40 h. The reaction mixture was filtered and the filtrate was concentrated in vacuo. The residue was purified via preparative HPLC to afford 4,5-difluoro-2-piperazin-1-yl-benzenesulfonamide (400.00 mg, 1.15 mmol, 23% yield, 80% purity) as a white solid. MS (EI+, m/z): 278.1 [M+H]+.
The synthetic route of 43204-63-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Navitor Pharmaceuticals, Inc.; O’Neill, David John; Saiah, Eddine; Kang, Seong Woo Anthony; Brearley, Andrew; Bentley, Jonathan; (519 pag.)US2018/127370; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary