33070-32-5, name is 5-Bromo-2,2-difluorobenzodioxole, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 5-Bromo-2,2-difluorobenzodioxole
Example 1 : 3-(2,2-Difluoro-benzo[1 ,31dioxol-5-ylmethyl)-piperidine-1 -carboxylic acid pyridin-3-ylannide.Step A: 3-(2,2-Difluoro-benzo[1.SIdioxol-delta-ylnnethvD-piperidine-i-carboxylic acid tert-butyl ester.; 1 -Boc-3-methylene piperidine (842 mg, 4.27 mmol) was degassed (neat) for 15 minutes and then treated with a THF solution of 9-BBN (0.5 M in THF, 8.6 ml_, 4.3 mmol). The reaction mixture was refluxed for 2 h, then cooled to rt. The reaction mixture was then added, via cannula, to a preformed solution of 5-bromo-2,2-difluoro-1 ,3-benzodioxole (1.00 g, 4.22 mmol), Pd(dppf)CI2?CH2CI2 (94 mg, 0.128 mmol), and potassium carbonate (746 mg, 5.40 mmol) in DMF/H2O (10 mL/1 ml_). The resultant mixture was heated at 60 0C for 18 h, cooled to rt, poured into water, basified to pH 11 with 1 N NaOH, and extracted with EtOAc (3x). The organic layers were combined, dried (Na2SO4), and concentrated. The crude residue was purified (FCC) to give 3-(2,2-difluoro-benzo[1 ,3]dioxol-5-ylmethyl)- piperidine-1 -carboxylic acid tert-butyl ester (1.00 g, 67%).
The synthetic route of 33070-32-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; BREITENBUCHER, J., Guy; KEITH, John, M.; TICHENOR, Mark, S.; CHAMBERS, Alison, L.; JONES, William, M.; HAWRYLUK, Natalie, A.; TIMMONS, Amy, K.; MERIT, Jeffrey, E.; SEIERSTAD, Mark, J.; WO2010/68452; (2010); A1;,
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