Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 766-46-1, name is 2′-Bromophenylacetylene, A new synthetic method of this compound is introduced below., name: 2′-Bromophenylacetylene
General procedure: All reactions were carried out under aerobic conditions. A mixture of aromatic alkyne (1.0 mmol), AgNO3 (0.075 mmol), Cs2CO3 (1.0 mmol), catalyst compound 1 (0.5 mol %), and n-butyl alcohol/H2O (in 1:2 proportion, 3 mL) was stirred at 60 C for 24 h and then extracted three times with ethyl acetate (3 x 15 mL). The combined organic phase was dried with MgSO4, filtrated, and then solvent was removed on a rotary evaporator. The product was isolated by thin-layer chromatography. The purified products were identified by 1H-NMR and 13C-NMR spectroscopy (Figures S1-S10).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Guo, Mengping; Chen, Bo; Lv, Meiyun; Zhou, Xiuling; Wen, Yongju; Shen, Xiuli; Molecules; vol. 21; 5; (2016);,
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