Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 337915-79-4, name is 5-Bromo-N1-methylbenzene-1,2-diamine, A new synthetic method of this compound is introduced below., SDS of cas: 337915-79-4
Step C6-bromo- 1 -methyl- 1 H-benzimidazol-2-[00304] A solution of (2-amino-5-bromophenyl)methylamine (992 mg, 4.93 mmol) inMeOH (10 mL) was treated with cyanogen bromine (1045 mg, 9.87 mmol). The reaction mixture was maintained at room temperature for 1 h, then partitioned between EtOAc (100 mL), a sat. NaHC03 solution (100 mL) and water (20 mL). The organic layer was washed with a sat. NaCI solution, dried (Na2S04) and concentrated. The residue was triturated using CH2CI2 to obtain 6- bromo-1-methyl-1 H-benzimidazol-2-amine (952 mg, 4.21 mmol, 85 % yield) as a beige solid:.1H NMR (400 MHz, DMSO-cfe) delta ppm 3.48 (s, 3 H) 6.57 (s, 2 H) 7.04 (d, J=0.98 Hz, 2 H) 7.30 – 7.38 (m, 1 H) ES LC-MS m/z =226.1 (Br79, M+H)+; ES LC-MS m/z =228.1 (Br81, M+H)+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GLAXOSMITHKLINE LLC; BOTYANSZKI, Janos; DICKERSON, Scott Howard; LEIVERS, Martin Robert; LI, Xiaofei; MCFADYEN, Robert Blount; REDMAN, Aniko Maria; SHOTWELL, John Bradford; XUE, Jianjun; WO2012/174312; (2012); A2;,
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