In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17247-58-4, name is (Bromomethyl)cyclobutane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of (Bromomethyl)cyclobutane
Example 5; Preparation of N-cyclobutylmethyl-6,14~endoethano-7-(2-hydroxy-2-cyclobutyl-2-ethyl)-tetrahydronorthebaine (compound (VI); R1 and R2= cyclobutyl); 596 mg (4 mmol) of bromomethyl cyclobutane, 1 g (7.2 mmol) of potassium carbonate and 1 g (2.5 mmol) of the compound of formula (V) obtained in Example 4 were added slowly to 10 ml of dimethylformamide. The resulting mixture was heated to 135 C and stirred for 3 hours. The excess potassium carbonate was removed by filtration, and the solvent was removed by vacuum distillation. The remaining solid was filtered and vacuum dried to obtain the title compound (0.94 g, 81%).
The synthetic route of 17247-58-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HANMI PHARM. CO., LTD.; WO2006/25710; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary