Application of 1422-54-4, The chemical industry reduces the impact on the environment during synthesis 1422-54-4, name is 2-Bromo-6-fluorotoluene, I believe this compound will play a more active role in future production and life.
The boronate ester (151 mg) and 2-bromo-6-fluoro-toluene (139 mu) were dissolved in dioxane (3 mL). K3PO4.7H2O (373 mg) and PdCI2(PPh3)2 (26 mg) were added under an N2-atmosphere and the resulting mixture was subjected to microwave irradiation (250W, 120C, 60-90 min.). The reaction mixture was cooled, filtered over a layer of decalite and washed with ethyl acetate. Evaporation of the solvent and chromatography over silica gel with ethyl acetate/heptane afforded 3-(2-chlorophenyl)-4-(2-methyl-3-fluorophenyl)-5-(4-methoxyphenyl)- isoxazole (124 mg).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-6-fluorotoluene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; N. V. ORGANON; DIJCKS, Fredricus Antonius; VEENEMAN, Gerrit Herman; PETERS, Johannes Lambertus Maria; WO2012/52395; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary