Month: December 2020

Reference of 698-00-0, The chemical industry reduces the impact on the environment during synthesis 698-00-0, name is 2-Bromo-N,N-dimethylaniline, I believe this compound will play a more active role in future production and life.

Example No. 6: Preparation of Compound No. 6[0294] A solution of 2,8-dimethyl-2,3,4,5-tetrahydro- lH-pyrido[4,3-b]indole (0.2 g, 1 mmol), (2-bromo-phenyl)-dimethyl-amine (600 mg, 3 mmol), K3PO4 (636 mg, 3 mmol), L-Proline (69 mg, 0.6 mmol) and Cul (57 mg, 0.3 mmol) in dry DMF (4 mL) was stirred at 150 C for 16h. The reaction mixture was cooled to RT, diluted with water and extracted with EtOAc. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford crude material, which was purified by column chromatography using neutral alumina and 10% EtOAc-Hexane followed by reverse phase HPLC purification to yield [2-(2,8- dimethyl-l,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-yl)-phenyl]-dimethyl-amine (20 mg). 1H NMR (TFA salt, CD3OD) delta (ppm): 7.50 (m, 1H), 7.38 (m, 2H), 7.18 (m, 2H), 7.0 (m, 2H), 4.75 (d, 1H), 4.40 (m, 1H), 3.80 (m, 1H), 3.58 (m, 1H), 3.15 (s, 3H), 3.0 (m, 1H), 2.70 (m, 1H), 2.56 (s, 6H), 2.42 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-N,N-dimethylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; PROTTER, Andrew, Asher; CHAKRAVARTY, Sarvajit; WO2012/112962; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 344-03-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 344-03-6, name is 1,4-Dibromotetrafluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

(A) Preparation of starting materials Synthesis of dimethylaminomethyl p-bromotetrafluorobenzene 10 g (32.5 mmoles) of 1,4-dibromotetrafluorobenzene are dissolved under argon in 100 ml of ether and 100 ml of tetrahydrofuran. The solution is cooled to -78¡ã C. and 21 ml of a 1.6 molar solution of butyllithium in hexane are added. After 15 minutes, 6.08 g (65 mmoles) of N,N-dimethylmethyleneimmonium chloride are added and the mixture is warmed to room temperature. After 11/2 hours the mixture is poured into water and extracted with ether. The ethereal extract is dried over MgSO4. The solvent is distilled off, affording as residue a white solid which is distilled at 100¡ã C. under a high vacuum. Yield: 7.8 g (84percent) of a colourless product which is solid at room temperature.

The chemical industry reduces the impact on the environment during synthesis 1,4-Dibromotetrafluorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Ciba-Geigy Corporation; US4590287; (1986); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 10016-52-1,Some common heterocyclic compound, 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, molecular formula is C12H6Br2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a two-necked flask were added A-1-1 (2.5 g), B-1 (3.6 g) And sodium tert-butoxide (4.4 g) was added thereto. The flask was filled with di-gassed toluene (46 mL) and heated to 100 C. Pd [P (t-Bu) 3] 2 (200 mg), Pd And the mixture was stirred at the same temperature for 17 hours. Diluted with DCM (100 mL) and filtered through SiO2. The filtered solution was depressurized to remove the solvent, and the residue was dissolved in THF in EA and then recrystallized to obtain A-1 (final) (1.5 g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,8-Dibromodibenzo[b,d]furan, its application will become more common.

Reference:
Patent; LG Chem, Ltd.; Lee Chung-hwan; Bae Jae-sun; Lee Jae-cheol; Kim Hwa-gyeong; Shin Ji-yeon; (37 pag.)KR2018/92782; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 67567-26-4, name is 4-Bromo-2,6-difluoroaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 67567-26-4

4-Bromo-2,6-difluoroaniline (65A, 0.50Og, 2.4mmol) was combined with sodium methanesul finale (0.98g, 9.6mmol), cuprous triflate benzene complex (0.121g, 0.24mmol), and N,N’-dimethylethylencdiamine (0.027mL, 0.23mmol) in DMF (5mL). The mixture was heated to 150 C and allowed to stir at this temperature for 24 hours, then was concentrated in vacuo and purified using PLC to provide compound 65B as a yellow solid.

The synthetic route of 67567-26-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; WO2009/55331; (2009); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 1647-26-3, A common heterocyclic compound, 1647-26-3, name is 1-Bromo-2-cyclohexylethane, molecular formula is C8H15Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 2; Synthesis of 3-(2-aminoquinazolin-6-yl)-1-(2-cyclohexylethyl)-4- methylpyridin-2(1 K)-one; To a solution of 3-(2-aminoquinazolin-6-yl)-4-methylpyridin-2(1 H)-one (103mg, 408 mumol, Example 1 , step 3) in DMF in a sealed tube was added sodium tert- butoxide (58.9 mg, 612 mumol). The mixture was stirred at RT for 5min and turned from clear yellow to a suspension of yellow solids. 1-bromo-2-cyclohexylethane (76.7 mul, 490 mumol) was then added and the resulting mixture was heated to 700C over the weekend. Reaction was cooled to RT and was quenched with Sat’d NH4CI and extracted with DCM. Purification by prep plate TLC (10% MeOH/DCM) produced the title compound as an off white solid. M+H= 363.2.

The synthetic route of 1647-26-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMGEN INC.; WO2008/11109; (2008); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 327-51-5

1,4-dibromo-2, 5-difluorobenzene (49.3 g, 181.5 mmol), 2-methoxyphenylboronic acid (66.2 g, 435.6 mmol), a 2 M aqueous solution of Na2CO3 (363 mL, 726 mmol), DME (360 mL), toluene (360 mL), and Pd[PPh3]4 (21 g, 18.0 mmol) were loaded into a three-necked flask, and the mixture was refluxed under an Ar atmosphere for 8 hours. After the completion of the reaction, the resultant was cooled to room temperature. The resultant sample was transferred to a separating funnel, and water (500 mL) was charged into the funnel. Then, the mixture was extracted with CH2Cl2. The extract was dried with MgSO4, and was then filtrated and concentrated. The resultant sample was purified by silica gel column chromatography, whereby a white solid was obtained in an amount of 38.5 g in 65% yield. FD-MS C20H16F2O2 : theoretical value 326, observed value 326

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 327-51-5.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2301921; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 630-17-1, name is 1-Bromo-2,2-dimethylpropane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 630-17-1, COA of Formula: C5H11Br

Example 2: Synthesis of posphoric acid mono-[2-(2, 2-dimethyl-propane-1-sulfonyl)-ethyl] ester A. 2-(2, 2-Dimethyl-propane-1-sulfonyl)-ethanol; A suspension of 2-mercapto-ethanol (110 mg, 1.41 mmol), 1-bromo-2, 2-dimethyl-propane (210 mg, 1.41 mmol) and K2C03 (195 mg, 1.41 mmol) in DMF (3 mL) was stirred at 60 C for 5 h. The reaction mixture was then cooled to room temperature and treated with a mixture of 2KHS05-KHS04 (1.30 g, 2.11 mmol) in water (0.5 mL). After stirring for 12 h at room temperature, the solvent was removed in vacuo, and the residue partitioned between ethyl acetate and water. The organic layer was dried over Na2S04, filtered, and concentrated in vacuo. The residue was purified by flash chromatography over silica gel (elution with hexane/ethyl acetate 4: 1) to give the title compound as a colorless oil. 1H NMR (300 MHz, DMSO-d6) 6 1.23 (s, 9H), 2.55 (s br. , 1H), 3.05 (s, 2H), 3.18-3. 23 (m, 2H), 4.09-4. 19 (m, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; JERINI AG; WO2005/80406; (2005); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 55289-36-6, name is 3-Bromo-2-methylaniline, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H8BrN

[0249] (a) 4-Bromoindazole. A 350 mL 5-necked flask was charged with benzene (127 mL) and potassium acetate (4.24 g, 43.2 mmol). 3-Bromo-2- methyl-aniline (6.00 g, 42.4 mmol) was added over a period of 5 min to the white suspension followed by acetic anhydride (12.0 mL, 127 mmol). A thick white suspension was formed at this point. The mixture was heated to 80C and isopentyl nitrite (8.46 g, 43.2 mmol) was added and the orange suspension was heated at 80C overnight. The reaction mixture was cooled, filtered and the filter cake was washed with benzene (3×30 mL). The filtrate was concentrated under reduced pressure to remove the solvent and the residue was heated to 60C. Cone. HCl (2.0 mL) was added and the mixture was stirred at 7O0C for 1 h. More cone. HCl was added (2.0 mL) and the mixture was stirred at 70C for 3 h. The mixture was cooled, diluted with water and toluene until the solid was completely dissolved. The layers were separated and the aqueous layer was extracted with toluene (3×50 mL). The combined organics were concentrated until product began to crystallize. The suspension was cooled to 0C and the precipitated solid was filtered to provide 4-bromoindazole as a beige solid (4.45 g, 53%).

The synthetic route of 55289-36-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LOCUS PHARMACEUTICALS, INC.; WO2008/8059; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 615-87-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 615-87-2, name is 1,5-Dibromo-2,4-dimethylbenzene, This compound has unique chemical properties. The synthetic route is as follows.

Into an eggplant type flask having a capacity of 200 milliliter, dbb in an amount of 5.11 mmol (1.35 g), (2-pyridyl)trimethyl tin in an amount of 15.3 mmol (3.71 g), Pd (PPh3)2Cl2 in an amount of 0.408 mmol (0.286 g), lithium chloride in an amount of 51.1 mmol (2.17 g) and toluene as a solvent in an amount of 20 milliliter were placed and the resultant solution was refluxed for 3 days. After the resultant solution was cooled by leaving it standing, saturated potassium fluoride aqueous solution was added and the resultant solution was stirred for 30 minutes. After filtering the resultant solution, dichloromethane and 5 % sodium hydrogen carbonate aqueous solution were added to the filtrate and the resultant solution was extracted. Adding sodium sulfate into an organic layer and dehydrating the resultant mixture, the organic layer was removed through pressure reduction, and the remained substance was refined by means of silica gel column chromatography (hexane : ether= 4:1). After re-crystallizing the resultant substance with the use of heated hexane, white crystals of dpyx in an amount of 0.31 g was obtained (yield: 33 %). m.p.: 89 to 90 C

The chemical industry reduces the impact on the environment during synthesis 1,5-Dibromo-2,4-dimethylbenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; Chuo University; EP1816134; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 698-19-1, These common heterocyclic compound, 698-19-1, name is 1-(2-Bromophenyl)-N-methylmethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of compound 1A (1.0 g, 5 mmol) in 50 mL of DCM was added N-Boc-glycine (950 mg, 5.4 mmol), followed by [1-HYDROXY-7-AZABENZOTRIAZOLE] (800 mg, 5.84 mmol) and [1- (3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE] hydrochloride (4.41 g, 7.38 mmol). The reaction mixture was stirred at rt for 4 hours and concentrated under reduced pressure. The resulting oil was dissolved in EtOAc and washed successively with saturated sodium bicarbonate, 1N-hydrochloric acid, dried over sodium sulfate and concentrated under reduced pressure to give the title compound (1.8 g, 99%) as a colorless oil, which was used for the subsequent step without further purification

Statistics shows that 1-(2-Bromophenyl)-N-methylmethanamine is playing an increasingly important role. we look forward to future research findings about 698-19-1.

Reference:
Patent; Bristol-Myers Squibb Company; WO2004/214; (2003); A2;,
Bromide – Wikipedia,
bromide – Wiktionary