Electric Literature of 1647-23-0, The chemical industry reduces the impact on the environment during synthesis 1647-23-0, name is 1-Bromo-3,3-dimethylbutane, I believe this compound will play a more active role in future production and life.
6-t-butyll-8-H-pteridinone (50 mg, 0.21 mmol, from preparative example 3) in 1 mL DMF was added 60 mg potasium carbonate and 1.5equiv. of 1-bromo-3,3-dimethylbutane. The reaction mixture was stirred at rt for 4 hours. The solid was filtered. The filtrate was concentrated. The residue was purified by column chromotagraphy (silica gel, 4:1 hexanes:ethyl acetate) to give 51 mg desired product. LC-MS [M+1]=319.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3,3-dimethylbutane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Zhu, Song; US2005/250779; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary