Adding a certain compound to certain chemical reactions, such as: 18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18648-66-3, Safety of 2-(4-Bromophenyl)-1,1-diphenylethylene
theTriphenylethylene bromide (3.35g,10.0mmol) dissolved in 20ml of tetrahydrofuran,cool down to -78 C, slowly drop wise added 2.5M n-butyllithium solution(4.0ml,10.0ml). After the addition was complete for 2 h, N, N-dimethylformamide(1.46g,20.0ml)was added, naturally heated to room temperature and kept thereaction for 24 h. The reaction was terminated, extraction was carried out withwater,after organic phase was dried over anhydrous sodium sulfate and dried invacuo on a rotary evaporator to give the crude product. The product waspurified by silica gel column chromatography; the eluent was a mixed solvent ofdichloromethane and n-hexane with volume ratio of 3:1. Pure product as a whitesolid, 3.3 g (yield 81%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(4-Bromophenyl)-1,1-diphenylethylene, and friends who are interested can also refer to it.
Reference:
Patent; Sun Yat-sen University; Ma, ChunPing; Chi, ZhenGuo; Zhou, Xie; Zhang, Yi; Liu, SiWei; Xu, JiaRui; (14 pag.)CN103804318; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary