Reference of 626-40-4, These common heterocyclic compound, 626-40-4, name is 3,5-Dibromoaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
cross-coupling reaction, the 11.87g, 40mmo 1 of 3,5-dibromoaniline, 9mL, 1OOmmo 1 of ethyl acrylate, 10.35g, 75mmol of anhydrous potassium carbonate, 3.22g, lOmmol tetrad Ammonium bromide and 1.122g, 5mmol of palladium acetate (catalyst) according to the set stoichiometric ratio uniformly dissolved in 100mL of DMF, the reaction was stirred at 130 C for 1 ~ 2 days, through a mixture of ethyl acetate and water Times extraction, drying over anhydrous magnesium sulfate, purification by chromatography and subsequent hydrolysis to obtain 5-amino-1,3-benzenediacrylic acid with high chemical purity.
Statistics shows that 3,5-Dibromoaniline is playing an increasingly important role. we look forward to future research findings about 626-40-4.
Reference:
Patent; Zhejiang University; Qian Guodong; Zhang Ling; Jiang Ke; Yang Yu; Cui Yuanjing; (7 pag.)CN106588960; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary