Electric Literature of 876-53-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 876-53-9 as follows.
General procedure: A solution of 43 g (0.2 mol) of 1-bromoadamantane in 260 mL of methylene chloride was cooled to -10 C, and 61.9 g (0.23 mol) of aluminum bromide was added. The mixture was stirred for 0.5 h, 44 mL (40 g, 0.42 mol) of isopropenyl acetate was added over a period of 2 h, and the mixture was stirred for 0.5 h, poured onto 200 g of ice, and made weakly alkaline reaction by adding sodium carbonate (106 g, 1 mol) and sodium metabisulfite (38 g, 0.2 mol). The organic layer was separated, and the aqueous layer was extracted with methylene chloride (3 ¡Á 50 mL). The extracts were combined with the organic phase, the solvent was distilled off, and the residue was distilled under reduced pressure. Yield 31.9 g (83%), bp 110-112 C (4 mm). 1H NMR spectrum (DMSO-d6), delta, ppm: 1.50-1.80 m (12H, CH2), 1.94 s (3H, CH), 2.10 s (3H, CH3), 2.16 s (2H, CH2CO).
According to the analysis of related databases, 876-53-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Novakov; Orlinson; Savel?ev; Potaenkova; Vostrikova; Tarakanov; Nakhod; Russian Journal of General Chemistry; vol. 87; 12; (2017); p. 2762 – 2765; Zh. Obshch. Khim.; vol. 87; 12; (2017); p. 1942 – 1946,5;,
Bromide – Wikipedia,
bromide – Wiktionary