Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7745-91-7, name is 3-Bromo-4-methylaniline, A new synthetic method of this compound is introduced below., COA of Formula: C7H8BrN
A cooled (0 0C) solution of 3-bromo-4-methylaniline (ABCR; 1.00 g; 5.37 mmol) in pyridine (20 ml) was treated with methanesulfonyl chloride (500 mul; 6.45 mmol). The reaction mixture was allowed to warm to RT and stirred for 1 hour, then EtOAc was added and the organic layer was washed with a 1 N aqueous solution of HCI. The organic layer was dried over MgSO4, filtered and concentrated to dryness to give the title compound as a brown solid (1.42 g, quantitative).1H NMR (300MHz, DMSO-d6) delta [ppm] 9.81 (1 H, s), 7.40 (1 H, d, J= 2.1 Hz), 7.31 (1 H, d, J= 8.3 Hz), 7.13 (1 H, d, J= 8.3 Hz, J= 2.1 Hz), 2.99 (3H, s), 2.29 (3H, s)
The synthetic route of 7745-91-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SERONO S.A.; CROSIGNANI, Stefano; JORAND-LEBRUN, Catherine; CLEVA, Christophe; PRETRE, Adeline; WO2010/92043; (2010); A1;,
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