Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 69321-60-4, name is 2,6-Dibromotoluene, A new synthetic method of this compound is introduced below., Recommanded Product: 69321-60-4
A mixture of 1,3-dibromo-2-methylbenzene (6.0 g, 24 mmol), phenylboronic acid(2.9 g, 24 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complexedwith dichloromethane (1: 1) (817 mg, 1. 0 mmol) and potassium carbonate (1 0 g, 725 mmol) in 1,4-dioxane (100 mL) and water (70 mL) was stirred at room temperatureovernight. The reaction was quenched with water, and extracted with ethyl acetate (3x 150mL). The combined organic layers were washed with brine, dried over Na2S04, filtered andconcentrated under reduced pressure. The residue was purified by chromatography on silicagel, eluting with 0-5% EtOAc/hexanes, to give the desired product (4.7 g).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; INCYTE CORPORATION; LU, Liang; QIAN, Ding-Quan; WU, Liangxing; YAO, Wenqing; (103 pag.)WO2017/205464; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary