Adding a certain compound to certain chemical reactions, such as: 630-17-1, name is 1-Bromo-2,2-dimethylpropane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 630-17-1, COA of Formula: C5H11Br
Example 2: Synthesis of posphoric acid mono-[2-(2, 2-dimethyl-propane-1-sulfonyl)-ethyl] ester A. 2-(2, 2-Dimethyl-propane-1-sulfonyl)-ethanol; A suspension of 2-mercapto-ethanol (110 mg, 1.41 mmol), 1-bromo-2, 2-dimethyl-propane (210 mg, 1.41 mmol) and K2C03 (195 mg, 1.41 mmol) in DMF (3 mL) was stirred at 60 C for 5 h. The reaction mixture was then cooled to room temperature and treated with a mixture of 2KHS05-KHS04 (1.30 g, 2.11 mmol) in water (0.5 mL). After stirring for 12 h at room temperature, the solvent was removed in vacuo, and the residue partitioned between ethyl acetate and water. The organic layer was dried over Na2S04, filtered, and concentrated in vacuo. The residue was purified by flash chromatography over silica gel (elution with hexane/ethyl acetate 4: 1) to give the title compound as a colorless oil. 1H NMR (300 MHz, DMSO-d6) 6 1.23 (s, 9H), 2.55 (s br. , 1H), 3.05 (s, 2H), 3.18-3. 23 (m, 2H), 4.09-4. 19 (m, 2H).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; JERINI AG; WO2005/80406; (2005); A2;,
Bromide – Wikipedia,
bromide – Wiktionary