Related Products of 698-19-1, These common heterocyclic compound, 698-19-1, name is 1-(2-Bromophenyl)-N-methylmethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of compound 1A (1.0 g, 5 mmol) in 50 mL of DCM was added N-Boc-glycine (950 mg, 5.4 mmol), followed by [1-HYDROXY-7-AZABENZOTRIAZOLE] (800 mg, 5.84 mmol) and [1- (3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE] hydrochloride (4.41 g, 7.38 mmol). The reaction mixture was stirred at rt for 4 hours and concentrated under reduced pressure. The resulting oil was dissolved in EtOAc and washed successively with saturated sodium bicarbonate, 1N-hydrochloric acid, dried over sodium sulfate and concentrated under reduced pressure to give the title compound (1.8 g, 99%) as a colorless oil, which was used for the subsequent step without further purification
Statistics shows that 1-(2-Bromophenyl)-N-methylmethanamine is playing an increasingly important role. we look forward to future research findings about 698-19-1.
Reference:
Patent; Bristol-Myers Squibb Company; WO2004/214; (2003); A2;,
Bromide – Wikipedia,
bromide – Wiktionary