Related Products of 74586-53-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74586-53-1 name is 3-Bromo-5-methylaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 1 : A solution of 3-bromo-5-methylaniline (162.5 g, 873.66 mmol) in 1,4- dioxane (2 L) was prepared, and 2-chloro-4-(trifluoromethyl)pyrimidine (182 g, 994.54 mmol) and methanesulfonic acid (97.5 g, 1.02 mol) were added sequentially. The resulting solution was heated to reflux overnight. The resulting mixture was cooled and concentrated in vacuo. The residue was diluted with 2 L of water, then adjusted to pH 7-8 with aqueous saturated sodium bicarbonate solution, followed by extraction with EtOAc (2×2 L). The organic layers were combined, washed with water (2x 2 L), dried over anhydrous sodium sulfate and concentrated in vacuo to afford N-(3-bromo-5-methylphenyl)-4-(trifluoromethyl)pyrimidin-2-amine as a light yellow solid. MS ESI calc’d for Ci2H10BrF3 3 [M + H]+ 332, 334, found 332, 334. NMR (400 MHz, CDCI3): delta 8.68 (d, J= 4.9 Hz, 1 H), 7.79 (s, 1 H), 7.33-7.23 (m, 2 H), 7.10-7.06 (m, 2 H), 2.36 (s, 3 H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromo-5-methylaniline, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MERCK CANADA INC.; HAIDLE, Andrew, M.; KNOWLES, Sandra Lee; KATTAR, Solomon, D.; DESCHENES, Denis; BURCH, Jason; ROBICHAUD, Joel; CHRISTOPHER, Matthew; ALTMAN, Michael, D.; JEWELL, James, P.; NORTHRUP, Alan, B.; BLOUIN, Marc; ELLIS, John, Michael; ZHOU, Hua; FISCHER, Christian; SCHELL, Adam, J.; REUTERSHAN, Michael, H.; TAOKA, Brandon, M.; DONOFRIO, Anthony; WO2013/192098; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary