In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 703-91-3, name is 5-Bromo-2-(trifluoromethyl)aniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 5-Bromo-2-(trifluoromethyl)aniline
Pd(dppf)Cl2 (613 mg, 0.84 mmol) was added to a mixture of 5-bromo-2- (trifluoromethyl)aniline (Int 25a) (2.00 g, 8.37 mmol), cyclopropylboronic acid (929 mg, 12.56 mmol) and Na2CO3(1.77 g, 16.70 mmol) in dioxane (25 mL) and the mixture was stirred at 90 C overnight. The mixture was concentrated to dryness and the residue was purified by column chromatography (0-2% EtOAc in PE) to give the title compound as yellow oil.
The synthetic route of 703-91-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; DEUSCHLE, Ulrich; ALBERS, Michael; HOFFMANN, Thomas; (64 pag.)WO2018/141855; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary