In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1647-23-0 as follows. Computed Properties of C6H13Br
To a mixture of 2-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4,6-bis(trifluoromethyl)- 2H-pyrazolo[3,4-d]pyrimidin-3-amine (100 mg, 0.21 mmol, 1 equiv), l-bromo-3,3- dimethylbutane (69.3 mg, 0.42 mmol, 2 equiv) in CH3CN (3.0 mL) was added potassium iodide (KI; 34.9 mg, 0.21 mmol, 1 equiv) and K3P04 (89.2 mg, 0.42 mmol, 2 equiv). The dark mixture was heated at 60 C for 5 h. The cooled mixture was diluted with EtOAc and washed with 0 (10 mL). The organic phase was concentrated in vacuo to give a residue, which was purified by preparative TLC to give the title compound (23 mg, 19.6%) as a yellow solid: ]H NMR (300 MHz, CDC13) delta 7.84 (s, 2H), 5.20 (br s, 1H), 2.91 – 2.84 (m, 2H), 1.46 – 1.41 (m, 2H), 0.77 (s, 9H); ESIMS m/z 568 [(M+H)]+.
According to the analysis of related databases, 1647-23-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; DOW AGROSCIENCES LLC; POBANZ, Mark A.; DENT, William Hunter; BENKO, Zoltan L.; ERICKSON, W. Randal; GENG, Chaoxian; WATSON, Gerald B.; SPARKS, Thomas C.; PATNY, Akshay; WO2014/126580; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary