Synthetic Route of 6627-78-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6627-78-7, name is 1-Bromo-4-methylnaphthalene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
In a 100 ml three-necked flask, compound 4”’ (10 mmol, 2.48 g) and THF (50 ml) were added, and n-butyllithium (11 mmol, 1.6 M, 6.88 ml) was slowly added dropwise under nitrogen atmosphere at -78C. The reaction was carried out at -78C for 2 hours, and then 5 ml of a THF solution of triisopropyl borate (15 mmol, 3.03 g) was slowly added dropwise to the reaction system. After the addition was completed, the mixture was slowly warmed to room temperature and stirred overnight. After the disappearance of the TLC test material, the reaction was completed. reaction. The mixture was quenched with dilute hydrochloric acid (20%, 20 ml), stirred at room temperature for 3 hours, then extracted with ethyl acetate (50 ml*3), and the combined organic phases were washed with saturated brine (100 ml*3) and dried over anhydrous sodium sulfate. The organic phase was concentrated and purified by column chromatography to give compound 3”’ (7.8 mmol, 1.45 g, 78%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-methylnaphthalene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Jiangsu Ailikang Pharmaceutical Co., Ltd.; Chen Lei; Xing Xiaolan; Liu Yuxian; Lu Pingbo; (12 pag.)CN107814795; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary