Related Products of 937046-98-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 937046-98-5 name is 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 7-bromopyrrolo[2,l- f][l,2,4]triazin-4-amine (2 g, 9.39 mmol, 2.98 equiv) in anhydrous THF (200mL) under inert atmosphere, was added 1,1 ,4,4-tetramethyl- 1 ,4-dichlorodisilyethylene(2. 2 g, 9.46 mmol, 1.1 equiv) along with sodium hydride (754 mg, 18.92 mmol, 2.2 equiv) and the mixture was stirred for 20 mm at room temperature. The reaction was then cooled to -78C before nbutyllithium (11.4 mL, 28.38 mmol, 2.5 M in hexanes) was added slowly over 10 mm. The reaction was allowed to stir for a further 15 mm before (3R,4 R, 5R)-3,4-bis(benzyloxy)-5- [(benzyloxy)methyl]oxolan-2-one (3.6 g, 8.60 mmol, 1.00 equiv) (dissolved in 5 mL THF) was added dropwise. The resulting solution was stirred for 1 h at -78 C, then quenched by the addition of 200 mL sat. ammonium chloride (aq.). The resulting solution was extracted with of ethyl acetate (200 mL x 3) and the organic layers combined, dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by reverse phase flash chromatography (ACN/H20). This resulted in 2 g (42%) of the title compound as a yellow solid. MS m/z [M+H] (ESI):553.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, and friends who are interested can also refer to it.
Reference:
Patent; ALIOS BIOPHARMA, INC.; BEIGELMAN, Leonid; DEVAL, Jerome; PRHAVC, Marija; (145 pag.)WO2019/53696; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary